Persistent Stunning Induces Myocardial Hibernation and Protection

Persistent stunning induces myocardial hibernation and protection: flow/function and metabolic mechanisms.

To test the hypothesis that persistent myocardial stunning can lead to hibernating myocardium, 13 pigs were chronically instrumented, and persistent stunning was induced regionally by 6 repetitive episodes of 90-minute coronary stenosis (CS) (30% reduction in baseline coronary blood flow [CBF]) followed by full reperfusion every 12 hours. During the 1st CS, CBF fell from 43+/-2 to 31+/-2 mL/min...

Stunning, hibernation, and assessment of myocardial viability.

The last 3 decades have witnessed an unprecedented improvement in the outcome of patients with acute coronary syndromes. The widespread use of thrombolytic therapy and percutaneous coronary interventions, in association with increasingly potent antithrombotic agents, has contributed to significant reductions in mortality and morbidity in these patients. Although overall survival has improved, a...

Myocardial hibernation and stunning: from physiological principles to clinical practice.

In patients with coronary artery disease, one of the most powerful determinants of prognosis is left ventricular function. 2 Thus, if we assume that the prognostic benefit of revascularisation is mediated through an eVect on left ventricular function, two mechanisms might explain this benefit. First, coronary artery bypass surgery or angioplasty could reduce the impact of coronary artery diseas...

Repeated stunning precedes myocardial hibernation in progressive multiple coronary artery obstruction.

OBJECTIVE The aim of this study was to characterize a regional myocardial flow-function relationship in collateral dependent myocardium produced by multiple coronary artery obstruction. METHODS Ameroid constrictors were placed around the proximal right (RC) and circumflex (CX) coronary arteries and a silicon tubing cuff around the proximal LAD (left anterior descending artery) (luminal stenos...

PRO: Stunning and hibernation: two faces of the same disease